Medicinal plants with promising anticolinesterasic activity: a systematic review

Abstract

Alzheimer's disease (AD) It is a neurodegenerative disorder characterized by a gradual onset and cognitive symptoms of progressive decline in multiple areas of functioning. This disorder has not yet drugs able to stop the course of the disease. therapeutic approaches have been developed over the past few years, aiming to enhance the functioning of the cholinergic system of patients with AD. The method which has proved most effective is currently the inhibition of acetylcholinesterase. Thus, this study aimed to add evidence about the medicinal plants with high action anticholinesterasic for a possible cholinergic treatment of AD, in order to avoid side effects than existing drugs provide. To this was performed a systematic review on the topic, in accordance with the Preferred reporting items for systematic reviews and meta-analyzesPRISMA. Articles published between the years 2002-2016 present in the PubMed database, Bireme, Scielo and Google Scholar. The evaluated data showed that the study of plant extracts belonging to various families could inhibit the activity of AChE enzyme. Associations which presents enzyme inhibition greater than or equal to 50% inhibition, are strong candidates to purification and isolation of active to inhibit the enzyme acetylcholinesterase principles. Thus, the constant search for AChE inhibitors for the treatment of AD found in the study of plants producing these inhibitors potentially a means of reducing costs and increasing accessibility to treatment.