Pulmonary Tuberculosis Related to Medicinal Resistence in the Population: a systematic review

Abstract

INTRODUCTION: Tuberculosis is a pathology with diverse descriptions in past societies, so its impact on society remains high, contributing to over 1.5 million deaths in 2014 alone. The discovery of mycobacterial therapy can be considered dating back to the last century, and since then few new drugs have been developed to combat this epidemic. Along with their emergence, reports of resistance are common, especially with monotherapy regimens. Certainly, by dealing with an old pathology such as TB, it is known that multidrug resistance is not new and, since the 1990s, the World Health Organization has started the creation of directives, strategies and committees aimed at reducing the prevalence and mortality of tuberculosis seeking to increase access to therapy, as well as the adequate control of its use in order to avoid the creation of new resistances. OBJECTIVE: The objective of this study is to verify drug resistance to tuberculosis through the analysis of articles. METHODOLOGY: The searches were performed in the bibliographic databases, Pubmed, Scielo, VHL and science direct. After applying inclusion and exclusion criteria, 20 articles were selected. Parameters such as recent publications and articles related to the theme were highlighted. CONCLUSION: The patient should be individually analyzed regarding the parameters of Immunological System, previous pathological history and educational level, as these are fundamental factors to obtain a good outcome of tuberculosis, as it is facing an extensive treatment pathology. and it has several multiresistant strains.